Induces Degradation of Myosin Heavy Chain via p38 MAPK and Muscle-Specific E3 Ubiquitin Ligases in C2 Skeletal Myotubes

Fig. 1 Effects of ONOO− on viability of myotubes. Myotubes were exposed to 25 μM ONOO− for 1, 2, and 6 h. Untreated myotubes served as control (CTL). Following incubation, viability of myotubes was assessed by the MTT assay. Results are means ± SE of 3 independent experiments. 3.2 ONOO− Activates p38 MAPK p38 MAPK…

Peroxynitrite Induces Degradation of Myosin Heavy Chain via p38 MAPK and Muscle-Specific E3 Ubiquitin Ligases in C2 Skeletal Myotubes

The dependency of autophagy and ubiquitin proteasome system during skeletal muscle atrophy

Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and mice

Cancer cachexia: molecular mechanisms and treatment strategies, Journal of Hematology & Oncology

Peroxynitrite Induces Degradation of Myosin Heavy Chain via p38 MAPK and Muscle-Specific E3 Ubiquitin Ligases in C2 Skeletal Myotubes

The E3 Ligase MuRF1 Degrades Myosin Heavy Chain Protein in Dexamethasone-Treated Skeletal Muscle - ScienceDirect

Transgenic Overexpression of Locally Acting Insulin-Like Growth Factor-1 Inhibits Ubiquitin-Mediated Muscle Atrophy in Chronic Left-Ventricular Dysfunction

Proteoglycan Extracted from Ganoderma lucidum Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro

Walk the Line: The Role of Ubiquitin in Regulating Transcription in Myocytes

PDF] Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes.

A critical discussion on the relationship between E3 ubiquitin ligases, protein degradation, and skeletal muscle wasting: it's not that simple

Frontiers Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis

IJMS, Free Full-Text

Mononucleated muscle product cells are active in DNA synthesis. (A)

Signaling Mechanisms in Mammalian Myoblast Fusion